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目的:对重症狼疮性肾炎应用利妥昔单抗治疗的效果进行探讨。方法:选取64例重症狼疮性肾炎患者作为研究对象,按照治疗方法的差异性对其分组,对照组32例给予激素联合霉酚酸酯治疗,观察组32例给予激素联合利妥昔单抗治疗,比较两组治疗效果。结果:治疗总有效率方面:观察组为90.62%,对照组为62.50%,数据组间差异明显,存在统计学意义(P<0.05)。临床指标方面:与对照组相比,观察组后24h尿蛋白、血尿素氮和Cr、SLEDAI评分均比较优,t检验组间,存在统计学意义(P<0.05)。结论:对重症狼疮性肾炎患者应用激素联合利妥昔单抗治疗的效果比较显著,故有进一步推广的价值。
Objective: To investigate the effect of rituximab in the treatment of severe lupus nephritis. Methods: Sixty-four patients with severe lupus nephritis were selected as study subjects and divided into groups according to the difference of treatment methods. Thirty two cases in the control group were treated with steroid combined with mycophenolate mofetil. In the observation group, 32 cases were treated with steroid combined with rituximab , Comparing the treatment effect of two groups. Results: The total effective rate of treatment was 90.62% in the observation group and 62.50% in the control group, with significant difference between the data groups (P <0.05). Clinical indicators: Compared with the control group, 24h urine protein, blood urea nitrogen and Cr, SLEDAI score were better, t-test group, there was a statistically significant (P <0.05). Conclusion: The treatment of severe lupus nephritis patients with hormone combination rituximab effect is more significant, so there is the value of further promotion.