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目的:探讨雌激素受体(ER)、孕激素受体(PR)及C-erbB-2、P53、nm23基因在乳腺癌组织中的表达及其与临床病理特征之间的关系。方法:用免疫组织化学S-P法检测113例乳腺癌组织中ER、PR及C-erbB-2、P53、nm23的表达。并结合乳腺癌临床病理特征进行分析。结果:113例乳腺癌组织中ER、PR及C-erbB-2、P53、nm23阳性表达率分别为49.6%、39.8%、59.3%、40.7%和71.7%,与临床分期、肿瘤大小、病理类型、年龄无关(P>0.05);C-erbB-2、P53阳性表达率与腋淋巴结转移呈正相关(P<0.05)。nm23阳性表达率与腋淋巴结转移呈负相关(P<0.05)。ER和(或)PR、nm23阳性组乳腺癌复发率低于阴性组(P<0.05)。C-erbB-2、p53阳性组乳腺癌复发率高于阴性组(P<0.05)。C-erbB-2的表达在ER、PR阴性组高于阳性组(P<0.05)。结论:联合检测ER、PR与C-erbB-2、P53、nm23表达对判断乳腺癌的预后、指导临床治疗具有十分重要的意义。
Objective: To investigate the expression of estrogen receptor (ER), progesterone receptor (PR), C-erbB-2, P53 and nm23 in breast cancer and their relationship with clinicopathological features. Methods: The expressions of ER, PR, C-erbB-2, P53 and nm23 in 113 cases of breast cancer were detected by immunohistochemical S-P method. Combined with clinical and pathological features of breast cancer analysis. Results: The positive expression rates of ER, PR, C-erbB-2, P53 and nm23 in 113 cases of breast cancer were 49.6%, 39.8%, 59.3%, 40.7% and 71.7% respectively, which were correlated with clinical stage, tumor size, (P> 0.05). The positive rates of C-erbB-2 and P53 were positively correlated with axillary lymph node metastasis (P <0.05). The positive rate of nm23 was negatively correlated with axillary lymph node metastasis (P <0.05). The recurrence rate of ER and / or PR and nm23 positive group was lower than that of negative group (P <0.05). The recurrence rate of C-erbB-2 and p53-positive breast cancer was higher than that of negative group (P <0.05). The expression of C-erbB-2 in ER, PR negative group was higher than that in positive group (P <0.05). Conclusion: The combined detection of ER, PR and C-erbB-2, P53, nm23 expression is of great significance in judging the prognosis of breast cancer and guiding the clinical treatment.