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以异海松酸(IPA)为原料,通过羧基酰氯化、肼解和缩合3步反应,合成了5种异海松酸基酰腙化合物(Ⅲa~Ⅲe)。目标化合物的结构通过IR、~1HNMR、~(13)CNMR和MS分析得到确证,并通过MTT法测试目标产物对小鼠HepG2癌细胞的抑制活性。结果表明,5种化合物对小鼠HepG2癌细胞均表现出抑制活性,其中,化合物Ⅲa和Ⅲc在浓度为100μmol/L时对小鼠HepG2癌细胞表现出显著的抑制活性,抑制率分别为75.42%和70.50%。
Five isopimaric acid acylhydrazone compounds (Ⅲa ~ Ⅲe) were synthesized by isopimaric acid (IPA) as starting material through three steps of carboxyl acyl chloride, hydrazinolysis and condensation. The structures of the target compounds were confirmed by IR, ~ 1HNMR, ~ (13) CNMR and MS analysis. The inhibitory activity of the target product on HepG2 cells was tested by MTT assay. The results showed that all of the five compounds showed inhibitory activity against HepG2 cells. Among them, compounds Ⅲa and Ⅲc showed remarkable inhibitory activity against HepG2 cells at a concentration of 100 μmol / L, with inhibitory rates of 75.42% And 70.50%.