为从昆虫来源的放线菌次级代谢产物中寻找药物先导分子,对铜绿金龟子幼虫肠道链霉菌Streptomyces sp.BCa1菌丝体化学成分进行了研究。通过活性跟踪,从其菌丝体的氯仿甲醇萃取物中分离得到主要成分1。利用高分辨质谱、一维和二维核磁波谱技术,将该主要成分1鉴定为具有双重旋转对称结构的不饱和大环内酯类抗生素阿扎霉素(elaiophylin),具有显著的抗金黄色葡萄球菌活性。该类化合物为首次从昆虫来源的放线菌中发现。 In order to search for drug lead molecules from secondary metabolites of actinomycetes originating from insect sources, the chemical constituents of the mycelia of Streptomyces sp. BCa1 from the green chafer larvae were studied. Through activity tracing, the main component 1 was isolated from the chloroform methanol extract of its mycelium. The main component 1 was identified as elaiophylin, an unsaturated macrolide antibiotic with a double rotational symmetry structure by high resolution mass spectrometry, one-dimensional and two-dimensional nuclear magnetic resonance spectroscopy, with significant anti-Staphylococcus aureus active. This class of compounds is found for the first time from insect-derived actinomycetes.