质子泵抑制剂(PPIs)是目前国内外使用最广泛的治疗酸相关性疾病(如胃食管反流性疾病、消化性溃疡)以及幽门螺杆菌感染、上消化道出血等的首选药物。它们特异性地作用于胃黏膜壁细胞而不可逆地抑制胃壁细胞中H~+,K~+-ATP酶(质子泵)的活性,从而发挥强大的抑制胃酸分泌的作用,其临床治疗地位在今后一段时间内不会被其他类别的药物所 Proton pump inhibitors (PPIs) are currently the most widely used domestic and international treatment of acid-related diseases (such as gastroesophageal reflux disease, peptic ulcer) and Helicobacter pylori infection, upper gastrointestinal bleeding and other drug of choice. They act specifically on gastric mucosal parietal cells and irreversibly inhibit the activity of H ~ +, K ~ + -ATPase (proton pump) in gastric parietal cells, thus exerting a strong inhibitory effect on gastric acid secretion. The clinical therapeutic status is in the future For some time will not be other types of drugs