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本研究检测了３４例正常育龄妇女放置左旋１８－甲基炔诺酮宫内节育器（ＬＮＧ－ＩＵＤ－２０）前、后子宫内膜血管内皮细胞因子Ⅷ（ＦⅧ）的活性。ＰＡＰ法染色，计算机数字化图象分析系统测定ＦⅧ活性的灰度值。结果：置器１２个月后，子宫内膜血管内皮细胞ＦⅧ活性大部分较放器前明显减弱（Ｐ＜０．００１），少数前后不变。提示ＬＮＧ－ＩＵＤ－２０可能干扰了子宫内膜血管内皮细胞ＦⅧ的合成、释放。
This study examined the activity of endometrial vascular endothelial cell factor Ⅷ (FⅧ) in 34 normal women of reproductive age before and after placement of levonorgestrel IUD (LNG-IUD-20). PAP staining, computerized image analysis system to determine the activity of the gray-scale value of F Ⅷ. Results: After 12 months of implantation, most of the FⅧ activity of endometrial vascular endothelial cells was significantly weaker than before (P <0.001). It is suggested that LNG-IUD-20 may interfere with the synthesis and release of FⅧ in endometrial vascular endothelial cells.