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目的观察消溃汤灌肠对湿热内蕴型溃疡性结肠炎模型大鼠症状改变及结肠黏膜修复的影响,为临床使用消溃汤治疗湿热内蕴型溃疡性结肠炎提供理论依据。方法建立湿热内蕴型溃疡性结肠炎模型大鼠,随机分为五组,分别给予消溃汤正常剂量、中等剂量、高剂量、美沙拉嗪及生理盐水灌肠,观察模型大鼠症状学评分及结肠黏膜形态学、组织学评分变化。结果在症状学大便性状评分方面消溃汤正常剂量组、中等剂量组、高剂量组、美沙拉嗪疗效优于生理盐水组(P<0.05),高等剂量和中等剂量组、正常剂量组及美沙拉嗪组比较无显著差异(P>0.05);在症状学大便带血评分,结肠黏膜形态学、组织学评分变化方面消溃汤正常剂量组、中等剂量组、高剂量组、美沙拉嗪优于生理盐水组(P<0.05),但高等剂量优于中等剂量组、正常剂量组及美沙拉嗪组(P>0.05)。结论消溃汤灌肠能明显改善模型大鼠症状,有效修复模型大鼠结肠黏膜组织,其中以消溃汤高剂量组为甚。
Objective To observe the effect of Xiaoke Tang enema on the symptoms of damp - heat intrinsic ulcerative colitis model rats and colon mucosal repair, and provide the theoretical basis for clinical treatment of damp - heat intrinsic ulcerative colitis with Xiao Kui Tang. Methods The rat model of damp - heat intrinsic ulcerative colitis was established and randomly divided into five groups. The rats were treated with Xiao Kui Tang normal dose, middle dose, high dose, mesalazine and saline respectively. The symptomology scores of model rats were observed. Colon mucosal morphology, histological score changes. Results In symptomology stool performance score, the effect of Xiao Kuantang normal dose group, middle dose group, high dose group and mesalazine group were better than those of normal saline group (P <0.05), high dose and middle dose group, normal dose group and the United States (P> 0.05). In the symptomological stool bloody score, colonic mucosa morphology and histological score changes, the normal dose group of Xiao Kui Tang, middle dose group, high dose group, mesalazine group (P <0.05), but the higher dose was better than the middle dose group, normal dose group and mesalazine group (P> 0.05). Conclusion Xiaoke Tang enema can significantly improve the symptoms of model rats and effectively repair the model of colonic mucosa in rats, especially in the high-dose group of Xiaoke decoction.