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[目的]应用磁共振波谱(MRS)定量分析评价人尿激肽原酶(HUK)治疗急性缺血性脑梗死(AIS)的疗效及对患者脑代谢物变化的影响.[方法]发病在72h内经核磁共振成像(MRI)确诊为AIS的患者38例,随机分为两组,对照组给予对症支持治疗,观察组在对照组的基础上给予HUK治疗.治疗前后应用MRS测定患者脑梗死周围区N-乙酰基天门冬氨酸(NAA)、肌酸(Cr)浓度,并应用美国国立卫生研究院卒中量表(NIHSS)、改良Rankin量表(mRS)评分,Barthel指数(BI)评价临床疗效.[结果]治疗前,两组梗死周围区NAA、NAA/Cr、两组NIHSS评分,mRS评分,BI指数相比较差异无显著性(P>0.05);治疗1周后,两组梗死周围区NAA、NAA/Cr均高于治疗前(P<0.05),且观察组梗死周围区治疗后NAA、NAA/Cr增加幅度高于对照组(P<0.05).两组治疗后较治疗前NIHSS评分和mRS评分降低、而BI指数升高(P<0.05),且观察组改善程度优于对照组(P 0.05)before the treatment.One week after treatment,the NAA and NAA/Cr in peripheral infarcted area of the two groups were higher than those before treatment(P <0.05).In the observation group,the increase of NAA and NAA/Cr in peripheral infarcted area was higher than that in the con-trol group(P <0.05).In regard to the NIHSS scores of the two groups after treatment,the mRS score decreased and the BI index increased compared with those before treatment(P <0.05),and the improvement degree of the observation group was better than that of the control group(P <0.05).[Conclusion]HUK treatment can improve the metabolism and clinical function of the brain cells around the infarcted area in AIS patients,and protect the nerve cells.