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生长激素缺乏症(GHD)是指生长激素(GH)分泌减少或者缺失导致生长发育障碍,是引起儿童身材矮小的重要原因之一。约95%患者无明确病因,称特发性GHD,其余的约5%为有明确病因的器质性GHD,约占[1-3]。特发性GHD按激素水平又可分为单纯GHD和联合垂体功能缺陷(MPHD),MPHD临床表现除身材矮小外还伴发尿崩症、性发育障碍、甲状腺功能减低及肾上腺皮质功能不全等[4]。近年来国内外临床报道特发性
Growth hormone deficiency (GHD) refers to the reduction of growth hormone (GH) secretion or lack of growth and development disorders, is caused by one of the important reasons for the short stature of children. About 95% of patients without a clear cause, said idiopathic GHD, and the remaining about 5% of a clear cause of organic GHD, accounting for about [1-3]. Idiopathic GHD according to hormone levels can be divided into simple GHD and joint pituitary dysfunction (MPHD), MPHD clinical manifestations in addition to short stature also accompanied by diabetes insipidus, sexual dysfunction, hypothyroidism and adrenal insufficiency [ 4]. In recent years, clinical reports at home and abroad idiopathic