论文部分内容阅读
目的探讨N-乙酰化转移酶2(NAT2)基因多态性与抗结核药物致肝损伤相关实验室指标的相关性。方法应用焦磷酸测序法检测抗结核治疗3个月内出现肝损伤患者41例和未出现肝损伤患者88例的NAT2基因多态性,并对所有患者肝功能检测指标进行分析。结果抗结核治疗后,不同NAT2乙酰基因型结核病病例的6项肝功能指标较治疗前均有升高(P均<0.01)。抗结核治疗后,不同基因型的ALT检测值之间存在差异(P<0.05),其中快乙酰型的ALT水平明显低于慢乙酰型(P<0.05);但其他5项肝功能指标在不同基因型间的差异均无统计学意义(P>0.05)。结论 NAT2基因多态性与患者治疗后ALT水平升高存在一定相关性,应重视该指标的变化。
Objective To investigate the relationship between polymorphism of N-acetyltransferase 2 (NAT2) gene and laboratory indexes related to hepatic injury induced by antituberculosis drugs. Methods Pyrosequencing was used to detect NAT2 gene polymorphism in 41 patients with liver injury and 88 patients without liver injury within 3 months after antituberculosis treatment. All patients’ liver function tests were analyzed. Results After anti-TB treatment, six indexes of liver function in different genotypes of NAT2 Acetylcholine were higher than those before treatment (all P <0.01). After anti-TB treatment, the ALT values of different genotypes were different (P <0.05), the fasting acetylcholine type ALT level was significantly lower than that of slow acetyl type (P <0.05); but the other five indicators of liver function were different There was no significant difference between genotypes (P> 0.05). Conclusion The polymorphism of NAT2 gene has some correlation with the increase of ALT level after treatment, and the changes of this index should be paid attention to.