目的观察长时间低频强噪声暴露对人体主要器官功能的影响,探讨其可能致伤机制。方法 2012-1-1/2014-8-31对20名长时间暴露于低频强噪声环境的工作人员进行追踪观察,对接触噪声过程中体温、呼吸、脉搏、血压进行间断监测,调查强噪声接触后的主要症状,并比较接触噪声前后血液常规、尿液常规、大便潜血试验、血液生化学、血皮质醇、心电图、胸部X线、腹部B超、脑电图、听阈、视力视野、听觉诱发电位的变化情况。结果 1低频强噪声暴露后,容易出现恶心、食欲下降、视物模糊、耳鸣、入睡困难等症状,其中耳鸣在低于6年接触者中容易出现,入睡困难在高于6年接触者中出现频率高。26年以上接触者在4000~8000 Hz听阈明显增高,同时听觉诱发电位显示Ⅴ波潜伏期延长,Ⅲ~Ⅴ、Ⅰ~Ⅴ峰间期明显延长。结论长时间接触低频强噪声可造成听力和中枢神经系统损害。 Objective To observe the effect of prolonged low-frequency and strong noise exposure on the function of major organs in human body and to explore its possible mechanism of injury. Methods January 20, 2012 / August 31, 2014 Twenty workers who were exposed to low frequency and strong noise for a long time were observed and monitored. Body temperature, respiration, pulse and blood pressure were monitored intermittently during the process of contact noise. After the main symptoms, and compare the noise before and after exposure to routine, urine routine, fecal occult blood test, blood biochemistry, blood cortisol, electrocardiogram, chest X-ray, abdominal B ultrasound, electroencephalogram, hearing threshold, visual field, auditory evoked Potential changes. Results 1 After low frequency and strong noise exposure, prone to nausea, loss of appetite, blurred vision, tinnitus, difficulty falling asleep and other symptoms, including tinnitus in less than 6 years, prone to contact, difficulty falling asleep occurred in more than 6 years of contacts High frequency. The hearing threshold of 4000 ~ 8000 Hz was significantly higher in contacts with more than 26 years, and the latent period of Ⅴ wave prolonged while the evoked potentials of Ⅲ ~ Ⅴ, Ⅰ ~ Ⅴ were significantly prolonged. Conclusion Long-term exposure to low-frequency and strong noise can cause hearing and central nervous system damage.