目的　探讨99Tcm TRODAT 1多巴胺转运蛋白SPECT脑显像在帕金森病亚临床期诊断中的价值。方法　对 4只食蟹猴静脉注射多巴胺转运蛋白显像剂99Tcm TRODAT 1,观察99Tcm TRODAT 1在不同时间点正常猴体内分布并进行纹状体DAT功能分析。用MPTP分别制备无症状亚临床期和临床期PD猴模型 ,利用计算机感兴趣区 (ROI)技术进行纹状体DAT功能半定量分析。结果　99Tcm TRODAT 1最佳SPECT脑显像时间为注射99Tcm TRODAT 1后 3～ 4h。PD猴毁损侧 (右侧 )纹状体在亚临床期就已存在DAT功能的降低 ,并随着损伤的加重毁损侧纹状体DAT功能进一步降低 ,对侧纹状体的DAT也受损。结论　99Tcm TRODAT 1SPECT脑显像可用于PD的亚临床期诊断和病情监测。 Objective To investigate the value of 99Tcm TRODAT 1 dopamine transporter SPECT brain imaging in the diagnosis of Parkinson’s disease. Methods Four cynomolgus monkeys were intravenously injected with 99Tcm TRODAT 1 dopamine transporter imaging agent to observe the distribution of 99Tcm TRODAT 1 in normal monkeys at different time points and analyze the DAT function of striatum. The asymptomatic subclinical and clinical models of PD monkeys were prepared by MPTP, and semi-quantitative analysis of DAT function of striatum was performed by computerized region-of-interest (ROI) technique. Results The best 99Tcm TRODAT 1 SPECT brain imaging time after injection of 99Tcm TRODAT 1 3 ~ 4h. The lesion side (right side) striatum of PD monkeys reduced the function of DAT in subclinical period and further reduced the function of DAT in the lesser striatum as the lesion was aggravated, and the DAT in the contralateral striatum also impaired. Conclusion 99Tcm TRODAT 1 SPECT brain imaging can be used for subclinical PD diagnosis and disease monitoring.