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目的:探讨尿毒症非透析患者脂蛋白(a)[Lp(a)]、尿酸(UA)及C反应蛋白(CRP)异常的临床意义。方法:分析47例尿毒症非透析患者血清Lp(a)、UA及CRP的水平与心血管疾病的关系。结果:尿毒症患者血Lp(a)、UA、CRP水平均较对照组呈显著性升高(P<0.01)。47例患者中有心血管疾病患者24例,无心血管疾病患者23例,心血管疾病组的Lp(a)、UA及CRP明显高于无心血管疾病组(P<0.01),且两组的Lp(a)、UA及CRP异常率差异有显著性(P<0.01)。多元Logistic逐步回归分析证实:Lp(a)、UA及CRP是心血管疾病的有关。结论:尿毒症患者存在脂质代谢紊乱、高尿酸血症及慢性炎症状态,Lp(a)、UA、CRP升高是导致尿毒症患者心血管并发症的危险因素。
Objective: To investigate the clinical significance of the abnormalities of lipoprotein (a) [Lp (a)], uric acid (UA) and C-reactive protein (CRP) in uremic nondialysis patients. Methods: The relationship between serum levels of Lp (a), UA and CRP and cardiovascular diseases in 47 patients with uremia without dialysis was analyzed. Results: The levels of Lp (a), UA and CRP in uremia patients were significantly higher than those in control group (P <0.01). Among the 47 patients, there were 24 patients with cardiovascular disease and 23 patients without cardiovascular disease. The Lp (a), UA and CRP in patients with cardiovascular disease were significantly higher than those without cardiovascular disease (P <0.01) a) There was significant difference in abnormal rate of UA and CRP (P <0.01). Multivariate Logistic stepwise regression analysis confirmed that: Lp (a), UA and CRP are related to cardiovascular disease. Conclusion: There are lipid disorders, hyperuricemia and chronic inflammation in patients with uremia. Elevated Lp (a), UA and CRP are the risk factors of cardiovascular complications in uremic patients.