目的对磺胺嘧啶钠注射液进行凝胶法干扰试验,建立磺胺嘧啶钠注射液细菌内毒素检查法的试验方法。方法采用《中国药典》2005年版二部附录细菌内毒素检查法。结果将磺胺嘧啶钠注射液稀释到浓度为2.5mg/ml时,不干扰细菌内毒素试验,其细菌内毒素限值为0.1EU/mg。结论使用细菌内毒素检查法检查磺胺嘧啶钠注射液中的细菌内毒素是可行的。 Objective To test the interference of sodium sulfadiazine injection by gel method and establish the test method of bacterial endotoxin test of sodium sulfadiazine injection. Methods The “Chinese Pharmacopoeia” 2005 edition two appendix bacterial endotoxin test. Results When sulfadiazine sodium injection was diluted to a concentration of 2.5 mg / ml, the bacterial endotoxin test was not disturbed with a bacterial endotoxin limit of 0.1 EU / mg. Conclusion It is feasible to use bacterial endotoxin test to check the bacterial endotoxin in sodium sulfadiazine injection.