①目的提取、纯化牛骨形态发生蛋白（ＢＭＰ）并验证其异位诱导成骨的活性。②方法采用生物化学方法提取并纯化出ＢＭＰ，植入家兔肌肉和豚鼠颅骨中进行动物实验研究。③结果植入ＢＭＰ组，１４ｄ即有成纤维细胞转化为成软骨细胞；第２１，２８天形成软骨和骨组织。成年豚鼠颅骨缺损修复实验中，植入ＢＭＰ后第２８天即有骨痂生成，８４ｄ时颅骨缺损修复完整。④结论ＢＭＰ有明显的异位诱导骨形成作用 Objective To extract and purify bovine bone morphogenetic protein (BMP) and verify its ectopic osteogenesis activity. ② Methods Biochemical methods were used to extract and purify BMP, and then implanted into rabbit muscle and guinea pig skull for animal experiments. ③ The results were implanted BMP group, 14d that fibroblasts into chondrocytes; the first 21,28 days to form cartilage and bone tissue. In adult guinea pig skull defect repair experiment, bone callus was formed on the 28th day after BMP implantation, and the skull defect was repaired completely on 84th day. ④ Conclusion BMP has obvious ectopic induction of bone formation