作者从美国儿科诊所挑选282名儿童,用双盲随机法给予醋氨酚或安慰剂。受试儿童共分成2、4、6、18月龄和4～6岁5个年龄组,于接种DTP前0～30分钟及接种后3、7、12和18小时分别给予40、80、80、120和240mg醋氨酚,接种后3、7、12和24小时测量体温,观察局部和全身反应。 145人给予醋氨酚,137人给予安慰剂。在5个年龄组中服药组反应均低于安慰剂组,在2和2～6月龄组有显著性差异。观察了13种接种反应,在服药组和安慰剂组65个反应率比较中,有43次服药组低于 The authors selected 282 children from a US pediatric clinic and randomized them to acetaminophen or placebo. The children were divided into 2, 4, 6, 18 months and 4 to 6 years old 5 age groups, 0 to 30 minutes before inoculation DTP and 3,7,12 and 18 hours after inoculation were given 40,80,80 , 120 and 240 mg acetaminophen, body temperature was measured at 3, 7, 12 and 24 hours after inoculation, and local and systemic reactions were observed. 145 were given acetaminophen and 137 were given placebo. The response rates in the 5 age groups were lower than those in the placebo group, with significant differences between 2 and 2 to 6 months of age. Thirteen inoculation responses were observed. Among the 65 response rates in the placebo and placebo groups, 43 were lower than