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目的:探讨p21WAF1/CIP1和抑制增殖细胞核抗原(PCNA)的表达与下咽癌、喉癌的分级、转移及预后 的关系,了解p21WAF1/CIP1在下咽癌、喉癌发生、发展中的作用以及与PCNA的相关性。方法:对45例下咽癌、25 例声门上型喉癌、23例声门型喉癌标本,用EnvisionHIS的方法检测p21WAF1/CIP1、PCNA的表达情况,并分析 p21WAF1/CIP1表达与下咽癌、喉癌临床病理特征、转移、复发和预后的关系。结果:p21WAF1/CIP1阳性表达率为51.6% (48/93),PCNA的阳性表达率为97.8%(91/93);p21WAF1/CIP1表达与下咽癌、喉癌患者的年龄、性别、肿瘤分化、远 处转移及复发无显著性相关,与肿瘤的原发部位的T分期有显著性相关;p21WAF1/CIP1的表达还与肿瘤的预后有显 著性相关;而PCNA与肿瘤的临床分期及淋巴转移有显著性相关,p21WAF1/CIP1与PCNA的表达具有相关性。结 论:p21WAF1/CIP1、PCNA是预测肿瘤浸润范围及转移的良好指标,p21WAF1/CIP1对预后的判定具有一定的指导意义。
Objective: To investigate the relationship between the expression of p21WAF1 / CIP1 and PCNA and the classification, metastasis and prognosis of hypopharyngeal carcinoma and laryngeal carcinoma and to investigate the role of p21WAF1 / CIP1 in the pathogenesis and development of hypopharyngeal carcinoma and laryngeal carcinoma. PCNA correlation. Methods: The expression of p21WAF1 / CIP1 and PCNA in 45 cases of hypopharyngeal carcinoma, 25 cases of supraglottic laryngeal carcinoma and 23 cases of glottic laryngeal carcinoma were detected by Envision HIS. The expressions of p21WAF1 / CIP1 and hypopharynx The relationship between clinicopathological characteristics, metastasis, recurrence and prognosis of carcinoma and laryngeal cancer. Results: The positive expression rate of p21WAF1 / CIP1 was 48.6% (48/93) and the positive rate of PCNA was 97.8% (91/93). The expression of p21WAF1 / CIP1 was correlated with the age, sex and tumor differentiation of patients with hypopharyngeal carcinoma and laryngeal carcinoma , Distant metastasis and recurrence were not significantly correlated with T stage of the tumor primary tumor was significantly related; p21WAF1 / CIP1 expression and prognosis of the tumor was significantly related to the PCNA and tumor clinical stage and lymph node metastasis There was a significant correlation between the expression of p21WAF1 / CIP1 and PCNA. Conclusion: p21WAF1 / CIP1 and PCNA are good predictors of the extent of tumor invasion and metastasis, and p21WAF1 / CIP1 is of guiding significance in the prognosis evaluation.