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恶性雀斑(Lentigo maligna, LM)是一斑状黑素细胞发育异常,好发于年老、皮肤色浅者,尤其是外露受光线照射之皮肤.它逐渐发展成肿瘤往往要1O～18年,称为恶性雀斑黑素瘤(Lentigo maligna melanoma, LMM),虽比别的恶性黑素瘤较少发生转移,但其预后仍不佳.在LM的“良性”阶段是一治疗并防止恶变的时机,不幸的是由于种种原因,约有1/3的LM在发展为恶性黑素瘤之前被忽略.手术切除后一般形成有碍美容的疤痕,因而为了达到较好的美容效果而常用:5-FU局部外用、放射疗法、冷冻疗法、电干燥法及刮除以及皮肤擦摩术等,这些方法的广泛应用使这种肿瘤的治愈率下降.
Maligna freckle (Lentigo maligna, LM) is a punctate melanocyte dysplasia, occurs in older, lighter skin, especially exposed skin exposed to light. It gradually developed into a tumor often requires 1O to 18 years, said Maligna melanoma (LMM) is less malignant than other malignant melanomas, but its prognosis is still poor. In the “benign” stage of LM is a treatment and prevention of malignant transformation. The timing, unfortunately, is due to various reasons, about 1/3 of the LM is ignored before the development of malignant melanoma. Surgical resection generally hinder the beauty of the scar, so in order to achieve a better cosmetic effect commonly used: 5 - FU topical application, radiation therapy, cryotherapy, electrodrying and scraping, and skin rubbing, etc., The wide application of these methods makes the cure rate of this tumor decreased.