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目的 :观察 3 0例肺癌组织及癌旁肺组织 MRP的表达。方法 :RT- PCR方法。结果 :4 3 .3 3 %的肺癌组织表达 MRP,且 MRP的表达与细胞分化程度有关 ,低分化者 MRP的表达明显高于中高分化者 ( P<0 .0 5 )。腺癌的表达 ( 62 .5 % )高于鳞癌 ( 2 1.4 3 % ,P=0 .0 5 8)。MRP的表达与临床分期无关 ( P=0 .5 11)。结论 :4 3 .3 3 %的肺癌组织表达 MRP,MRP的表达可能与肺癌的耐药有关
Objective: To observe MRP expression in 30 lung cancer tissues and adjacent non-cancerous lung tissues. Methods: RT-PCR method. Results: 43.3% of lung cancer tissues expressed MRP, and the expression of MRP was related to the degree of cell differentiation. The expression of MRP in poorly differentiated was significantly higher than that in moderately well differentiated (P <0.05). The expression of adenocarcinoma (62.5%) was higher than that of squamous cell carcinoma (2 1.4 3%, P = 0.058). The expression of MRP was not associated with clinical stage (P = 0.511). Conclusions: 43.3% of lung cancer tissues express MRP, the expression of MRP may be related to the resistance of lung cancer