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目的探讨胃源性哮喘患儿经雷尼替丁治疗的随访结果。方法对５２例经便携式２４小时ｐＨ自动记录仪确诊的胃食管返流（ＧＥＲ）阳性哮喘患儿加用雷尼替丁治疗３个月，临床随访２年；１７例治疗后第２次复查食道ｐＨ值。结果雷尼替丁治疗的有效率９３６％（４４／４７），治疗后酸性返流指数、最长返流时间、Ｂｏｉｘ－Ｏｃｈｏａ综合评分低于治疗前，Ｐ＜００５，而ｐＨ＜４的返流次数及返流≥５分钟的次数与治疗前无显著差异（Ｐ＞００５）。结论ＧＥＲ是诱发小儿哮喘的原因之一，ＧＥＲ阳性时胃酸分泌增多，雷尼替丁是治疗胃源性哮喘的有效药物。
Objective To investigate the follow-up results of ranitidine treatment in children with gastric asthma. Methods Renal gastroesophageal reflux (GER) -positive asthmatic children diagnosed by portable 24-hour pH automatic recorder were treated with ranitidine for 3 months and were followed up for 2 years. In the 17 cases, the second recurrent esophagus pH value. Results The effective rate of ranitidine treatment was 936% (44/47). After treatment, the index of acid reflux, the longest reflux time and the Boix-Ochoa comprehensive score were lower than those before treatment (P <005) The number of reflux <4 and reflux ≥ 5 minutes no significant difference with the treatment before treatment (P> 0 05). Conclusions GER is one of the causes of asthma in children. When GER is positive, gastric acid secretion increases. Ranitidine is an effective drug for the treatment of gastric asthma.