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目的研究讨论经过短期的胰岛素治疗对诱导2型糖尿病缓解的情况和远期临床疗效。方法选择2008年12月至2013年1月入院并且接受治疗的新诊2型糖尿病患者120例,年龄35～65岁,对其进行短期胰岛素治疗16天后,观察患者各项生理指标的变化,如血糖控制和胰岛素分泌功能,以及停药后血糖达标持续时间。结果 120位患者在接受短期胰岛素治疗后,空腹血糖、餐后2小时血糖及糖化血红蛋白等血糖控制指标均明显降低(P<0.01);停用胰岛素后,这些患者中血糖控制达标超过两个月的比例达到79.5%,超过六个月的患者占总人数的62.0%,而超过一年的患者占总人数的11.6%。结论对于新诊2型糖尿病患者,短期的胰岛素治疗能够显著改善血糖控制,并能在停药后较长时间维持血糖在可以接受范围内。
Objective To study the short-term insulin treatment to induce type 2 diabetes relief and long-term clinical efficacy. Methods A total of 120 newly diagnosed type 2 diabetic patients admitted to our hospital from December 2008 to January 2013 were enrolled in this study. The patients aged 35-65 years old underwent short-term insulin therapy for 16 days. The changes of various physiological indexes were observed. Glycemic control and insulin secretion, as well as the duration of glycemic control after withdrawal. Results Fasting plasma glucose, postprandial 2-hour postprandial glucose and glycosylated hemoglobin (HbA1c) control indexes were significantly decreased in 120 patients after short-term insulin treatment (P <0.01). After stopping using insulin, the blood glucose control in these patients reached the standard for more than two months 79.5% of all patients, 62.0% of patients over six months, and 11.6% of patients over one year. Conclusions Short-term insulin therapy significantly improves glycemic control in newly diagnosed type 2 diabetic patients and maintains acceptable blood glucose levels for a longer period after discontinuation.