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通过对托克逊县1986年——1991年6年期间肺结核治疗与1992年—1999年8年期间,实施世界银行贷款中国结核病控制项目(以下简称:世行项目)肺结核病采用标准化疗方案治疗后疗效分析研究,结果显示:前6年初治涂阳病例118人,痰菌阴转83.15%101人,初治阴转率85.59%复治涂阳病人60例,痰菌阴转47人,复治阳转率78.33%,初、复治涂阳病例平均痰菌阴转率83.15%。1992年—1999年8年期间,实施“世行项目”采用WHO推荐的短程间歇化疗方案及“全程督导”用药的管理方式,治疗涂阳病人409例,其中初治涂阳病人255例,采用初治涂阳方案:2H_3R_3Z_3S_3(E_3)/4H_3R_3,治疗2月末、5月末,疗程结束时初治涂阳阴转病例数和阴转率分别是:223例,87.4%,239例,93.7%;244例,95.6%,复治涂阳病人151例,治疗2月末、5月末,疗程结束时,复治痰涂阴转病例数和阴转串分别是:105例,69.5%,126例,83.4%,130例,86.0%。平均初复治痰涂阴转率为:92.11%。结果表明:标准化疗方案及“全程督导”化疗的管理措施,是保证病人规律治疗控制传染源,阻断流行的较佳方式,应大力推广应用。
Through the treatment of tuberculosis in Tuokexun County during the six years from 1986 to 1991 and the eight years from 1992 to 1999, the implementation of the standard chemotherapy regimen for the treatment of tuberculosis in the China Tuberculosis Control Project (World Bank Project) The results showed that in the first 6 years, 118 smear positive cases, 83.15% sputum negative conversion rates were 101 cases, the initial treatment negative conversion rate was 85.59%, 60 cases of retreatment smear positive cases, 47 cases of sputum negative conversion, Governing rate of 78.33%, initial sputum smear positive smear negative conversion rate of 83.15%. During the period from 1992 to 1999, 409 patients with smear positive were treated by the World Bank Project using the short-range intermittent chemotherapy recommended by the WHO and the administration mode of “full supervision”. Among them, smear-positive patients 255 patients were treated with initial treatment of smear: 2H_3R_3Z_3S_3 (E_3) / 4H_3R_3. The number of smear-negative patients and the negative conversion rate at the end of the treatment in the end of 2 and the end of 5 months were 223 cases, 87.4% and 239 cases , 93.7%; 244 cases, 95.6%, 151 cases of retreatment smear-positive patients, the end of treatment 2, end of 5 months, the end of treatment, 126 cases, 83.4%, 130 cases, 86.0%. The average rate of initial retreatment sputum smear negative conversion rate: 92.11%. The results showed that the standard chemotherapy regimen and management measures of “full supervision” and chemotherapy were the best ways to ensure that the regular treatment of patients controlled the source of infection and blocked the epidemic, and should be vigorously popularized and applied.