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目的:探讨纳络酮在各种急性中毒患者抢救中的临床效果。方法:回顾性分析我院急诊科2009年10月~2012年10月收治的320例急性中毒患者的病例资料,其中急性乙醇中毒125例、急性一氧化碳中毒137例、急性安眠药中毒30例、急性有机磷中毒28例。观察组选择采用纳络酮治疗的165例患者,对照组为采用常规治疗的155例患者,对比两组患者临床效果、清醒时间及不良反应发生情况。结果:观察组临床效果显著优于对照组,清醒时间较对照组有明显缩短,两组差异有统计学意义(P<0.05);两组患者用药过程中均未见明显不良反应发生。结论:纳络酮应用于乙醇、一氧化碳、安眠药、有机磷等急性中毒患者有较好的临床效果,值得在临床上推广使用。
Objective: To investigate the clinical efficacy of naloxone in the rescue of patients with acute poisoning. Methods: A retrospective analysis of emergency department of our hospital from October 2009 to October 2012 admitted 320 cases of acute poisoning patients, including acute ethanol poisoning in 125 cases, 137 cases of acute carbon monoxide poisoning, 30 cases of acute hypnosis poisoning, acute organic 28 cases of phosphorus poisoning. The observation group selected 165 patients treated with naloxone, the control group of 155 patients treated with conventional treatment, the clinical efficacy, awake time and adverse reactions in both groups were compared. Results: The clinical effect of the observation group was significantly better than that of the control group, and the awake time was significantly shorter than that of the control group. There was significant difference between the two groups (P <0.05). No obvious adverse reactions occurred in both groups. Conclusion: The application of naloxone in patients with acute poisoning such as alcohol, carbon monoxide, hypnotics and organic phosphorus has good clinical effect and is worth popularizing in clinic.