1 细胞凋亡的概念及其生物学意义 细胞凋亡(apoptosis)的概念,首先是由英国病理学家Kerr等在1972年提出的,用以描述一种在形态学上有别于细胞坏死(necrosis)的细胞死亡过程。细胞凋亡主要是指有核细胞在一定条件下,细胞表面分子接收到诱导因子刺激并将信号传入细胞内部,通过启动其自身内部遗传机制,形成级联式信息传导和基因表达,最终导致细胞死亡的过程。 1 The concept of apoptosis and its biological significance The concept of apoptosis, first proposed by British pathologist Kerr et al in 1972, is used to describe a concept that is morphologically distinct from cell necrosis necrosis cell death process. Apoptosis mainly refers to nucleated cells under certain conditions, the cell surface molecules to stimulate and receive signals to the cells inside, by initiating its own internal genetic mechanism to form a cascade of information transduction and gene expression, eventually leading to The process of cell death.