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目的：探讨转化生长因子β１（ＴＧＦβ１）、表皮生长因子受体（ＥＧＦＲ）在非小细胞肺癌中的表达及意义。方法：应用免疫组化法检测了１２１例非小细胞肺癌标本中ＴＧＦβ１、ＥＧＦＲ的表达。结果：ＴＧＦβ１在肺癌中的阳性表达分为间质型和胞浆型，总阳性表达率为７７．７％。ＴＧＦβ１的阳性表达类型与肺癌的淋巴结转移及预后有关，淋巴结转移阳性组ＴＧＦβ１的单一间质阳性表达率显著低于淋巴结阴性组，而单一胞浆阳性表达率高于淋巴结阴性组；半年内死亡组的ＴＧＦβ１单一间质阳性表达率低于５年以上生存组，而间质胞浆均阳性的表达率及单一胞浆阳性表达率则高于５年以上生存组（Ｐ均＜０．０５）。ＥＧＦＲ阳性表达率为４３．８％，其表达与淋巴结转移无关；与患者预后关系明显，ＥＧＦＲ阳性表达者预后差（Ｐ＜０．０５）。结论：ＴＧＦβ１、ＥＧＦＲ表达与肺癌恶性生物学行为关系明显，是评估患者预后的有效参数
Objective: To investigate the expression and significance of transforming growth factor β1 (TGFβ1) and epidermal growth factor receptor (EGFR) in non-small cell lung cancer. Methods: Immunohistochemistry was used to detect the expression of TGFβ1 and EGFR in 121 non-small cell lung cancer specimens. Results: The positive expression of TGFβ1 in lung cancer was divided into interstitial and cytoplasmic types, the total positive expression rate was 77.7%. The positive expression of TGFβ1 was related to the lymph node metastasis and prognosis of lung cancer. The positive rate of single interstitial expression of TGFβ1 in lymph node positive group was significantly lower than that in lymph node negative group, while the positive expression rate of single cytoplasm was higher than that in negative lymph node group. The positive rate of TGFβ1 expression in single stromal cells was lower than that in 5-year survival groups, while the positive expression rate of single interstitial cytoplasm and single cytoplasm positive expression rate of TGFβ1 was higher than that of 5-year survival group (all P <0.05). The positive expression rate of EGFR was 43.8%. The expression of EGFR was not associated with lymph node metastasis. The prognosis of patients with EGFR was significantly higher than that with EGFR positive (P <0.05). Conclusion: The expression of TGFβ1 and EGFR is significantly correlated with the malignant biological behavior of lung cancer, which is a valid parameter to evaluate the prognosis of patients