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目的分析中链饱和脂肪酸(MC-SFA,MCF组)、长链饱和脂肪酸(LC-SFA,LCF组)、n-6多不饱和脂肪酸(n-6PUFA,SUF组)和n-3多不饱和脂肪酸(n-3PUFA,TUF组)四种脂肪酸对大鼠血清生化指标及胰岛素抵抗的影响。方法雄性SD大鼠40只随机分为5组,对照组给予普通日粮,高脂组给予脂肪热量比相同的高脂日粮。喂养10w,每18d测定空腹血糖(GLU)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-c)、总胆固醇(TC)和血清胰岛素水平,根据胰岛素敏感性指数(ISI)=㏑1/(FPG×FINS)评定大鼠的胰岛素敏感性。结果10w后,LCF组和SUF组体重显著高于对照组和其它高脂组;LCF组和对照组血清TG显著高于其它高脂组(P<0.05);LCF组血清TC显著高于对照组和其它高脂组(P<0.05);高脂组血清HDL-c均显著低于对照组(P<0.05)并以TUF组下降幅度最大;LCF组血清胰岛素显著高于对照组(P<0.05);LCF组和TUF组ISI显著低于对照组(P<0.05);各组间血糖无明显差异(P>0.05)。结论不同类型脂肪酸对大鼠体重、血清生化指标及胰岛素抵抗的影响有显著差异。
Objective To analyze the effects of medium-chain saturated fatty acids (MC-SFA, MCF), long-chain saturated fatty acids (LCF), n-6 PUFA Effects of four fatty acids of fatty acids (n-3 PUFA, TUF group) on serum biochemical indexes and insulin resistance in rats. Methods Forty male Sprague-Dawley rats were randomly divided into five groups. The control group was given normal diet, and the high-fat diet group was given the same fat diet more than the same fat diet. The fasting blood glucose (GLU), triglyceride (TG), high density lipoprotein cholesterol (HDL-c), total cholesterol (TC) and serum insulin were measured every 18 days according to the insulin sensitivity index (ISI) = ㏑ 1 / (FPG × FINS) to assess insulin sensitivity in rats. Results After 10 weeks, the body weight of LCF group and SUF group was significantly higher than that of control group and other hyperlipidemia groups; the serum TG of LCF group and control group was significantly higher than that of other hyperlipidemia groups (P <0.05); the serum TC of LCF group was significantly higher than that of control group (P <0.05). The levels of HDL-c in high-fat diet group were significantly lower than those in control group (P <0.05), and those in TUF group were the highest. Serum insulin levels in LCF group were significantly higher than those in control group ). The ISI in LCF group and TUF group was significantly lower than that in control group (P <0.05). There was no significant difference in blood glucose between groups (P> 0.05). Conclusion Different fatty acids have significant effects on body weight, serum biochemical indexes and insulin resistance.