论文部分内容阅读
用大鼠和小鼠强迫游泳行为模型观察了吗氯贝胺的抗抑郁效应。大鼠一次给予吗氯贝胺１０－１００ｍｇ·ｋｇ￣（－１）无影响。２４ｈ内３次强化给药使游泳不动时间减少。若每日给药２次。连续１５次则不但效应进一步加强且呈较好的量效关系，同时活动性不增加。小鼠单次或３次强化给予吗氯贝胺对游泳不动时间均无明显影响。每日１次。连续给药２０ｄ，表现出与大鼠同样的良好效应和量效关系。活动性亦无增高。
The anti-depressive effects of moclobemide were observed using forced swimming behavior in rats and mice. Rats given a single dose of clomipine 10-100mg · kg ~ (-1) no effect. 3 times within 24 hours of intensive administration to reduce swimming time. If given daily 2 times. Continuous 15 times, the effect is not only further strengthened and showed a good dose-effect relationship, while not increasing activity. Mice were single or three times to strengthen the role of mocobinine swimming fixed time had no significant effect. 1 day. Continuous administration of 20d, showed the same good effect and dose-effect relationship with rats. No activity increased.