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目的综合评价IL-10(Interleukin-10)基因启动子1082位点多态性与乳腺癌易感性的关系。方法通过检索维普,万方,CNKI,Medline,SpringerLink和PubMed数据库,获取IL-10基因多态性与女性乳腺癌遗传易感性关系的研究结果,所纳入文献均采用病例--对照研究的设计,以乳腺癌组与对照组人群基因型分布的OR值为效应指标,采用RevMan4.2和STATA11软件进行Meta-分析及检验,并根据一致性检验的结果选用合适的模型(固定效应模型或随机效应模型)进行数据的合并。发表偏倚的评估使用漏斗图来进行,发表偏倚的检验使用Egger’s检验。结果 Meta分析共纳入6篇文献,累计共3698例,包括1823例肿瘤病例和1875例对照,A等位基因相对于G等位基因合并OR值为0.97,95%可信区间是0.87~1.09,差异无统计学意义(P=0.63)。结论 Interleukin-10基因1082A﹥G多态性与乳腺癌易感性无明显关联。
Objective To evaluate the relationship between the polymorphism of Interleukin-10 gene promoter at position 1082 and susceptibility to breast cancer. Methods The relationship between IL-10 gene polymorphism and genetic predisposition of female breast cancer was obtained by searching VIP, Wanfang, CNKI, Medline, SpringerLink and PubMed databases. The included references were all designed with case-control study, The OR value of genotype distribution in breast cancer patients and control subjects was taken as the effect index. Meta-analysis and test were performed by using RevMan4.2 and STATA11 software. According to the results of consistency test, appropriate models (fixed effects model or random effects Model) for data consolidation. Evaluation of publication bias was performed using a funnel plot and publication bias was tested using Egger’s test. Results A total of 6 articles were included in the meta-analysis, including a total of 3698 cases, including 1823 cases of cancer and 1875 cases of controls. The combined odds ratio (OR) of the A allele to the G allele was 0.97, the 95% confidence interval was 0.87 to 1.09, The difference was not statistically significant (P = 0.63). Conclusion Interleukin-10 gene 1082A> G polymorphism is not associated with breast cancer susceptibility.