环境内分泌干扰物毒理研究的现状及展望

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对环境内分泌干扰物问题产生的背景 ,其对人和野生生物的有害影响 ,以及目前对该问题严重程度的认识作了评论。认为 ,环境内分泌干扰物对人类生存环境和健康的影响是值得重视的 ,但也不必将问题过于严重化 ,提到威胁人类生存的严重程度。建议我国政府从现在开始着手拟定环境内分泌干扰物对人体健康影响的研究规划 ,成立有关协调小组 ,以环境雌激素研究为重点 ,以它们对生殖发育和致癌效应为主 ,以实验哺乳动物的毒理研究为手段 ,辅以必要的体外筛选实验 ,利用人群调查资料做出危险度评定。我国可能应以某些农药、人工合成的雌激素类药物、海洋污染物以及洗涤剂为重点。 The background to the issue of environmental endocrine disruptors, their harmful effects on humans and wildlife, and the current awareness of the magnitude of the problem are commented. It is worth noting that the impact of environmental endocrine disruptors on the living environment and health of human beings is worth noting. However, it is not necessary to over-scale the problem, referring to the serious threat to human existence. It is recommended that the government of our country start from now on to draw up a research plan on the impact of endocrine disruptors on human health and set up a coordination group focusing on environmental estrogen research with their emphasis on reproductive development and oncogenic effects in order to test the toxicity of mammals Rational research as a means, supplemented with the necessary in vitro screening experiments, the use of population survey data to make risk assessment. Our country should probably focus on certain pesticides, synthetic estrogens, marine pollutants and detergents.
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