AIM To evaluate the adequacy of the study of iron deficiency anemia(IDA)in real life practice prior to referral to a gastroenterology department for small bowel evaluation.METHODS All consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia,between January 2013 and December2015 were included.Both patients referred from general practitioners or directly from different hospital departments were selected.Relevant clinical information regarding prior anemia workup was retrospectively collected from medical records.An appropriate pre-referral study was considered the execution of esophagogastroduodenoscopy(EGD)with Helicobacter pylori(H.pylori)investigation,colonoscopy with quality standards(recent,total and with adequate preparation)and celiac disease(CD)screening(through serologic testing and/or histopathological investigation).RESULTS A total of 77 patients(58.4% female,mean age 67.1±16.7 years)were included.Most(53.2%)patients were referred from general practitioners,41.6% from other hospital specialties and 5.2% directly from the emergency department.The mean pre-referral hemoglobin concentration was 8.8±2.0 g/d L and the majority of anemias had microcytic(71.4%)and hypochromic(72.7%)characteristics.77.9%of patients presented with an incomplete pre-referral study:EGD in 97.4%,with H.pylori investigation in 58.3%,colonoscopy with quality criteria in 63.6%,and CD screening in 24.7%.Patients with an appropriate study at the time of referral were younger(48.7±17.7 vs 72.3±12.3 years,P<0.001).Small bowel evaluation was ultimately undertaken in 72.7%of patients,with a more frequent evaluation in patients with a quality colonoscopy at referral(78.6%vs 23.8%);P<0.001(OR=11.7,95%CI:3.6-38.6).The most common diagnosis regarded as the likely cause of IDA was small bowel angioectasia(18.2%)but additional causes were also found in the upper and lower gastrointestinal tracts of near 20% of patients.Small bowel studies detected previously unknown non-small bowel findings in 7.7% of patients.CONCLUSION The study of anemia prior to referral to gastroenterology department is unsatisfactory.Only approximately a quarter of patients presented with an appropriate study. AIM To evaluate the adequacy of the study of iron deficiency anemia (IDA) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. METHODS All consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia, Between January 2013 and December 2015 were included.Both patients referred from general practitioners or directly from different hospital departments were selected. Relevant clinical information regarding prior anemia workup was retrospectively collected from medical records. An appropriate pre-referral study was considered the execution of esophagogastroduodenoscopy ( EGD) with Helicobacter pylori (H. pylori) investigation, colonoscopy with quality standards (recent, total and with adequate preparation) and celiac disease (CD) screening (through serologic testing and / or histopathological investigation) .RESULTS A total of 77 patients ( 58.4% female, mean age 67.1 ± 16.7 years) were included. Host (53.2%) pa 41.6% from other hospital specialties and 5.2% directly from the emergency department. The mean pre-referral hemoglobin concentration was 8.8 ± 2.0 g / d L and the majority of anemias had microcytic (71.4%) and hypochromic (72.7%) characteristics.77.9% of patients presented with incomplete pre-referral study: EGD in 97.4%, with H.pylori investigation in 58.3%, colonoscopy with quality criteria in 63.6%, and CD screening in 24.7% .Patients with an appropriate study at the time of referral were younger (48.7 ± 17.7 vs 72.3 ± 12.3 years, P <0.001) .Smal bowel evaluation was ultimately undertaken in 72.7% of patients, with a more frequent evaluation in patients with a quality colonoscopy at referral (78.6% vs 23.8%); P <0.001 (OR = 11.7, 95% CI: 3.6-38.6). The most common diagnosis as the likely cause of IDA was small bowel angioectasia (18.2%) but more causes were also found in the upper and lower gastrointestinal tracts of near 20% of patients.Small bowel studies detected previously unknown non-small bowel findings in 7.7% of patients. CONCLUSION The study of anemia prior to referral to gastroenterology department is unsatisfactory. Notly a quarter of patients presented with an appropriate study.