乙型肝炎病毒(HBV)是一种非侵袭性嗜肝细胞病毒,感染人体后并不直接损害肝脏,而是引起细胞免疫和体液免疫应答,以细胞免疫反应损害肝细胞为主[1]。在大多数情况下,急性自限性肝炎患者会获得保护性的HBV特异性T淋巴细胞和B细胞免疫应答,控制病毒的复制和传播。然而,在HBV感染者中有超过400万患者会表现出慢性化,其是HBV复制和免疫应答不足的共同结果[2]。目前研究发现,慢性乙型肝炎 Hepatitis B virus (HBV) is a noninvasive hepatocytic virus that infects the human body without directly damaging the liver. Instead, it causes cellular and humoral immune responses, with the cellular immune response damaging to hepatocytes [1]. In most cases, patients with acute self-limiting hepatitis acquire a protective HBV-specific T-lymphocyte and B-cell immune response that controls the replication and spread of the virus. However, more than 4 million patients in HBV-infected individuals exhibit chronic disease, a common result of inadequate HBV replication and immune response [2]. The current study found that chronic hepatitis B