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作者对143例原发或继发性自身免疫性中性粒细胞减少症(AIN)病人的临床及实验室资料进行研究,这些病例系从1500例临床上可疑为AIN 病人中经血清学特异性自身抗体检测筛选出来的。除采用粒细胞免疫荧光试验(GIFT)及粒细胞凝集试验(GAT)检测病人血清标本中性粒细胞特异抗体外,还进行了血清特异性抗体类型及亚型测定、免疫复合物、普通血液学及骨髓等检查。结果,143例AIN 中,101例为原发性。42例为继发性。前者主要见于3岁以下儿童,诊断时平均年龄12个月,而后者多见于40～60岁成人。原发性AIN中,54%为女性,其余为男性。67例原发性AIN 在诊断时有不同程度的感染,以皮肤感染、中耳炎、上呼
The authors studied clinical and laboratory data from 143 patients with primary or secondary autoimmune neutropenia (AIN) from 1500 clinically suspicious AIN patients with serologically specific Autoantibodies were screened out. In addition to using GIFT and GAT to detect serum samples of patients with neutrophil-specific antibodies, serum-specific antibody types and subtypes, immune complexes, general hematology And bone marrow and other tests. Results, 143 cases of AIN, 101 cases were primary. 42 cases were secondary. The former is mainly seen in children under 3 years of age, the average age of diagnosis of 12 months, while the latter more common in adults 40 to 60 years. In primary AIN, 54% were women and the rest were men. 67 cases of primary AIN in the diagnosis of varying degrees of infection to skin infections, otitis media, call