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目的:探讨膜联蛋白A1在前列腺癌组织、癌旁组织及正常前列腺组织中的表达及意义。方法:应用免疫组织化学SABC法检测膜联蛋白A1在61例前列腺癌组织、40例癌旁组织、40例正常前列腺组织中的表达,分析其在不同组织中表达情况。结果:在前列腺癌组织、癌旁组织、正常前列腺组织中膜联蛋白A1的阳性表达率分别为19.67%,22.50%和72.50%(P<0.01)。前列腺癌组织中膜联蛋白A1表达在年龄、肿瘤大小、组织分化程度、肿瘤浸润深度、有无淋巴结转移、TNM分期及远处转移等方面差异均无统计学意义(P>0.05)。结论:膜联蛋白A1表达异常可能成为前列腺癌早期诊断的重要指标。
Objective: To investigate the expression and significance of annexin A1 in prostate cancer tissues, paracancerous tissues and normal prostate tissues. Methods: Immunohistochemical SABC method was used to detect the expression of Annexin A1 in 61 cases of prostate cancer, 40 cases of paracancerous tissues and 40 cases of normal prostate tissues. The expression of Annexin A1 in different tissues was analyzed. Results: The positive rates of Annexin A1 in prostate cancer tissues, paracancerous tissues and normal prostatic tissues were 19.67%, 22.50% and 72.50% (P <0.01), respectively. There was no significant difference in the expression of annexin A1 in prostate cancer tissues between age, tumor size, histological grade, depth of tumor invasion, lymph node metastasis, TNM stage and distant metastasis (P> 0.05). Conclusion: Abnormal expression of annexin A1 may be an important indicator of early diagnosis of prostate cancer.