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目的:探讨高海拔地区慢性胃炎的临床特征、病理特征及胃黏膜NO含量。方法:不同海拔地区慢性胃炎患者均行病理检查,并检测胃黏膜NO含量。结果:高海拔地区人群胃黏膜NO含量低于低海拔地区人群胃黏膜NO含量,高海拔地区慢性胃炎组胃黏膜NO含量平均为(11.50±4.37)μmoL/gprot,显著低于低海拔地区的慢性胃炎患者,差异有显性(P<0.01)。结论:高海拔地区由于长期缺氧胃黏膜保护性NO降低,减弱了改善胃黏膜微循环的生理功能,致慢性胃炎发病几率增高。
Objective: To investigate the clinical features, pathological features and gastric mucosal NO content of chronic gastritis in high altitude areas. Methods: The patients with chronic gastritis at different altitudes were examined by pathology, and the content of NO in gastric mucosa was detected. Results: The content of NO in gastric mucosa in high altitude area was lower than that in low altitude area. The content of NO in gastric mucosa was (11.50 ± 4.37) μmoL / gprot in chronic gastritis group at high altitude, which was significantly lower than that in low altitude Gastritis patients, the difference was significant (P <0.01). CONCLUSION: Due to the reduction of protective nitric oxide in long-term hypoxic gastric mucosa at high altitude, the physiological function of gastric mucosal microcirculation is weakened and the incidence of chronic gastritis is increased.