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AIM To study the effect of leukocyteendothelium interaction (LEI) on the flow anddistribution of leukocytes in microcirculationunder physiological condition.METHODS A microcirculation image multipleparameter computer analysis system (MIMPCAS)was used to study the flow and distribution ofleukocytes in mesentery microcirculation of ratsIn vivo.RESULTS The difference of visible leukocyteflux (VLF) was as high as 131 times in thearterioles and venules with similar diameter andblood velocity. The visible leukocytes rolledalong the blood vessel wall as a“ jerky”movement. The frequency distribution of thevisible leukocyte velocity (VLV) showed a “twopeak” Curve. The low peak value was at 10 pm/ s-- 15 pm/ s while the high peak fell between25 pm/ s-- 30 pm/ s. With the increase of diameterof venules, VLF increased while the VLVremained at the same level. With the increase ofRBC velocity, VLV trends to elevate and VLF tofal I down.CONCLUSION The results herein might providea basic theory for the study on the mechanism ofLEI under physiological condition and novelmethods for the prevention and treatment of highLEI in many pathological processes
AIM To study the effect of leukocyteendothelium interaction (LEI) on the flow and distribution of leukocytes in microcirculation of physiological conditions. METHODS A microcirculation image multipleparameter computer analysis system (MIMPCAS) was used to study the flow and distribution of leukocytes in mesentery microcirculation of rats In vivo. The difference of visible leukocyte flux (VLF) was as high as 131 times in the arterioles and venules with similar diameter and blood velocity. The visible leukocytes rolledalong the blood vessel wall as a “jerky ” movement. The frequency distribution of the visible leukocyte velocity (VLV ) The low peak value was at 10 pm / s-- 15 pm / s while the high peak fell between 25 pm / s-- 30 pm / s. With the increase of diameter of venules, VLF increased while the VLVremained at the same level. With the increase ofRBC velocity, VLV trends to elevate and VLF tofal I down. CONCLUSION The results herein might providea basic theory fo r the study on the mechanism ofLEI under physiological condition and novelmethods for the prevention and treatment of high LEI in many pathological processes