Sunahara曾报道人体唾液内可能存在一种氧化酶,在酸性条件下可将利福平氧化成醌式内核结构,抑菌活力降低。我国现在结核病临床治疗中使用的异丁基哌嗪力复霉素(商品名利福定),抗结核作用与利福平相似,它在体内是否也有此氧化代谢,对抑菌活性的影响如何,本文对此进行初步研究。 我们用酸化的健康人唾液或胃液,证实了Sunahara对利福平的实验结果。同样,利福定也能被酸化的唾液或胃液所氧化,由利福定原来的桔黄色变为暗紫色,光吸收曲线发生了明显变化,观察两者反应的颜色,似 Sunahara has reported that there may be an oxidase in human saliva, which oxidizes rifampicin to a quinoid core structure under acidic conditions and reduces antibacterial activity. Ispiperazine piperacillin (trade name rifampicin) used in the clinical treatment of tuberculosis in our country is similar to rifampicin in anti-tuberculosis effect. Whether it has this oxidative metabolism in vivo also has an impact on the antibacterial activity. This article conducted a preliminary study. We validated Sunahara’s experimental results of rifampin using acidified healthy human saliva or gastric fluid. Similarly, rifamycin can also be acidified saliva or gastric juice by the oxidation of the original rifampin orange to dark purple, light absorption curve changed significantly, the reaction between the two colors, like