磺胺药是一类临床常用的药物。它与一些药物合用时可产生相互作用,从而影响药物的疗效或产生不良反应,应予注意。一、磺胺药+碱化尿液的药物磺胺类药物中的磺胺嘧啶、磺胺二甲基嘧啶等在酸性尿液中其溶解度显著下降,易析出磺胺结晶,造成肾脏损害,而在碱性尿液中其溶解度则明显增高。因此,在应用上述磺胺药物时,应配伍碱性药物,以避免这些药物对肾脏的损害。临床上常用碱化尿液的药物是碳酸氢钠。二、磺胺药+氨甲喋呤氨甲喋呤是一种治疗剂量与中毒剂量很接近的抗代谢药。氨甲喋呤部分与血浆蛋白质结合。磺胺类药物能将结合型氨甲喋呤置换 Sulfa drugs are a class of commonly used drugs. It and some drugs can have an interaction when combined, thus affecting the efficacy of drugs or adverse reactions, should be noted. First, sulfa drugs + alkalinization of urine drugs sulfa drugs sulfadiazine, sulfamethazine, etc. its solubility in acidic urine decreased significantly, easy precipitation of sulfonamide crystals, resulting in kidney damage, and in alkaline urine In its solubility was significantly higher. Therefore, in the application of the above sulfa drugs, should be compatible with alkaline drugs, in order to avoid these drugs on the kidney damage. Alkalin commonly used in clinical medicine is sodium bicarbonate. Second, sulfa drugs + methotrexate Methotrexate is a therapeutic dose and poisoning dose is very close to anti-metabolism drugs. Methotrexate moiety binds to plasma proteins. Sulfa drugs can replace methotrexate