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目的探讨乌鲁木齐维吾尔族非妊娠女性细菌性阴道病(BV)和外阴阴道假丝酵母菌病(VVC)的危险因素以及局部免疫情况。方法随机选取210例非妊娠期维吾尔族女性进行阴道分泌物检查,并进行常规细菌和真菌培养,同时留取阴道盥洗液,上清进行细胞因子浓度检测,细胞进行荧光定量PCR检测干扰素-γ(IFN-γ)、白细胞介素-2(IL-2)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)mRNA水平,结合调查问卷对危险因素进行回归分析。结果 BV与年龄、居住地、文化程度和阴道冲洗因素有关。VVC与文化程度、职业、阴道冲洗因素有关。BV和VVC组阴道局部细胞因子IFN-γ下降,IL-10升高。结论 BV和VVC与阴道菌群失调有关,BV患者乳酸杆菌降低,加德纳菌增加,与年龄、居住地、文化程度和阴道冲洗因素有关。VVC病原体以白色假丝酵母菌为主,与文化程度、职业、阴道冲洗因素有关。BV和VVC患者阴道局部免疫以Th2免疫为主。
Objective To investigate the risk factors and local immune status of bacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) in Uyghur non-pregnant women in Urumqi. Methods 210 cases of non-pregnant Uigur women were randomly selected for vaginal discharge examination, and routine bacterial and fungal culture, vaginal washings were taken at the same time, the supernatant was measured cytokines, cells were detected by real-time quantitative PCR interferon-γ The levels of IFN-γ, IL-2, IL-4 and IL-10 mRNA were analyzed by regression analysis . Results BV was related to age, place of residence, educational level and vaginal washout factors. VVC and education, occupation, vaginal washing factors. Vaginal vaginal IFN-γ decreased and IL-10 increased in BV and VVC groups. Conclusions BV and VVC are related to the vaginal flora. BV patients with Lactobacillus decreased, Gardnerella increased, with age, place of residence, educational level and vaginal washing factors. VVC pathogens to Candida albicans, with the degree of education, occupation, vaginal washing factors. Vaginal local immunization in BV and VVC patients is based on Th2 immunity.