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我们应用体视学方法对高原实验家兔骨髓红细胞造血岛的形态进行了定量研究,发现动物进入高原低氧环境后,血岛的体积密度(Vv)和数量均有明显升高(P<0.01),差别显著。血岛细胞层次有变薄趋势。改变主要发生在高原第一、三周。高原第八周左右上述变化有向平原组回落的趋势。这与前期[1]所做的实验家免外用血红细胞计数等的研究结果相吻合。说明低氧通过机体调节系统能影响骨髓内红系造血组织。而血岛的体积密度、数量的增加属于骨髓组织对急性低氧的结构代偿性反应,随居留高原时间的延长,上述指标都会发生适应性回落。
We used stereological methods to study the morphology of rabbit bone marrow erythrocyte hematopoietic cells in plateaus experimentally and found that the volume density (Vv) and the number of blood islands were significantly increased after the animals entered the plateau hypoxic environment (P <0 .01), the difference is significant. Blood island cells have thinning trend. The change occurred mainly in the first three weeks of the plateau. In the eighth week of the plateau, the above-mentioned changes tended to decline towards the plain group. This is consistent with the results of previous studies [1] on the use of external red blood cell count and other experiments. Hypoxia through the body regulation system can affect erythroid hematopoietic tissue in the bone marrow. The density of blood island, the increase in the number of bone marrow tissue belonging to acute hypoxia structural compensatory response, with the stay of plateau extension of time, the above indicators will occur adaptive decline.