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作者以15名老年原发性高血压者同10名正常血压者作对照,研究了血浆醛固酮(PA)对限钠(每日25mEq共四天)和低钠摄入期间分级输注血管紧张素Ⅱ(AⅡ)(2、4、8ng/kg/min,各30分钟)的反应。结果如下:1,PA对限钠的反应:以限销后PA与血浆肾素活性(PRA)增加的比值(△PA/△PRA)来表示PA对限钠的反应与PRA之间的关系,在15例老年高血压者中有10例的△PA/△PRA同老年正常血压者相同。在摄入钠200mEq和25Eq期间,老年高血压组的血压增高的幅度较正常血压组增高为显著(P<0.001),而高血压组中△PA/△PRA正常者同增高者之间无显著差异。在限钠期间,老年高血压组中△PA/△PRA增高者较正常
The author of 15 elderly patients with essential hypertension and 10 patients with normal blood pressure were compared to study the effects of plasma aldosterone (PA) on sodium restriction (25mEq daily for four days) and low sodium intake during grading infusion of angiotensin II (AII) (2, 4, 8 ng / kg / min for 30 minutes each). The results are as follows: 1. Response of PA to sodium restriction: The relationship between PA response to sodium restriction and PRA was expressed as the ratio of PA to plasma renin activity (PRA) increase (△ PA / △ PRA) In 15 cases of elderly hypertensive patients, 10 cases of △ PA / △ PRA the same as the elderly with normal blood pressure. During 200 mEq sodium intake and 25Eq sodium intake, the increase of hypertension in elderly hypertension group was significantly higher than that of normotensive group (P <0.001), but there was no significant difference between hypertensive group and normal subjects difference. During sodium limitation, the increase in △ PA / △ PRA was more normal in the elderly hypertensive group