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目的探讨罗哌卡因配伍小剂量氯胺酮自控硬膜外镇痛用于分娩镇痛的临床效果。方法选择自愿接受分娩镇痛单胎初产妇130例,随机将其分为观察组与对照组,每组各65例。产程开始后,观察组注射罗哌卡因配伍小剂量氯胺酮,对照组仅注射罗哌卡因,观察两组产妇的镇痛效果、产程时间、缩宫素使用情况、分娩方式、产后2 h出血量以及新生儿情况等。结果给药后1 h、2 h两组产妇疼痛程度比较差异有统计学意义(P<0.05);两组在顺产率、器械助产率、剖宫产率和催产素使用率方面比较,差异均无统计学意义(P>0.05)。结论罗哌卡因配伍小剂量氯胺酮在自控硬膜外分娩镇痛中的应用是安全、有效的,可以减轻产妇的痛苦并且对母婴无不良反应,值得在临床上推广和应用。
Objective To investigate the clinical efficacy of ropivacaine combined with low dose ketamine controlled epidural analgesia in labor analgesia. Methods One hundred and thirty cases of single mothers with labor-induced analgesia were selected voluntarily. They were randomly divided into observation group and control group with 65 cases in each group. After the onset of labor, the observation group was given ropivacaine with a small dose of ketamine, and the control group with only ropivacaine. The analgesic effect, labor duration, oxytocin use, mode of delivery, and bleeding 2 h postpartum The amount of newborns and so on. Results There were significant differences in the degree of pain among the two groups at 1 h and 2 h after administration (P <0.05). The differences in the rates of cesarean section, cesarean section rate, cesarean section rate and oxytocin utilization rate between the two groups were statistically significant No statistical significance (P> 0.05). Conclusion The combination of low dose ketamine and ropivacaine is safe and effective in labor-controlled epidural analgesia. It can reduce maternal pain and has no adverse reactions to maternal and infant. It is worth popularizing and applying in clinic.