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本文为高能所快中子治疗装置的临床前先导研究。比较了35MeV P→Be产生的快中子和γ一次照射的生物效应。体外培养的V_(79)细胞,人鼻咽癌细胞和人黑色素瘤细胞的D_0值的中子RBE分别为1.4,1.8和2.4。小鼠移植性S-180肉瘤生长延迟的RBE值为3.2～3.3,皮肤早期损伤的RBE值为2.2～2.0,由此得出的中子治疗增益系数(TGF)为1.5～1.6。小鼠睾丸重最下降50％的RBE为2.0。小肠干细胞的RBE值约为1.5和1.4。人血淋巴细胞染色体畸变(双着丝点 +环)的RBE不是固定值。当中子剂量为1.0Gy时,RBE为2.3,当剂量提高到4.0时,RBE值为1.3。
This article is a preclinical pilot study of high energy fast neutron therapy devices. The biological effects of fast neutron and γ-irradiation produced by 35MeV P→Be were compared. The in vitro cultured V_(79) cells, human nasopharyngeal carcinoma cells, and human melanoma cells had D0 values of neutron RBE of 1.4, 1.8, and 2.4, respectively. The RBE value of the delayed growth of transplanted S-180 sarcoma in mice was 3.2-3.3, and the RBE value of early skin lesions was 2.2-2.0. The resulting neutron therapy gain factor (TGF) was 1.5-1.6. The RBE for the 50% drop in mouse testicle weight was 2.0. Intestinal stem cells have RBE values of approximately 1.5 and 1.4. The RBE of human blood lymphocyte chromosomal aberrations (double centromere + loop) is not a fixed value. When the neutron dose was 1.0 Gy, the RBE was 2.3, and when the dose was raised to 4.0, the RBE was 1.3.