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N-甲基异靛兰(代号靛Ⅲ),为靛玉红的类似物,对小鼠Lewis肺癌及大鼠Walker256有明显抑瘤作用,但对小鼠白血病L_(1210)。无效。对小鼠Lewis肺癌的疗效靛Ⅲ至少相当靛玉红的8倍。对狗的毒性靛Ⅲ比靛玉红高1倍多,主要毒性表现为胃肠道反应。该药无论腹腔注射或口服均可抑制[~3H]-TdR掺人大鼠Walker 256瘤细胞DNA。
N-Methylisothiocyanate (code name Indigo), an indirubin analogue, has obvious anti-tumor effect on mouse Lewis lung carcinoma and rat Walker256, but has no effect on mouse leukemia L 1210. invalid. The therapeutic effect on mouse Lewis lung cancer is at least 8 times that of indirubin. Toxicity to dogs is more than two times higher than that of indirubin. The main toxicity is gastrointestinal reaction. The drug inhibits [~ 3H] -TdR incorporation into rat Walker 256 tumor cell DNA either by intraperitoneal injection or oral administration.