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目的 探讨CA -Hb3在大肠癌患者血清中的水平及临床意义。方法 应用ELISA法 ,对 72例大肠癌患者血清CA -Hb3水平进行测定 ,并同期检测 36例健康人血清中的CA -Hb3水平作为对照。结果 大肠癌患者血清CA -Hb3水平显著高于正常人 ,CA -Hb3水平与大肠癌肿瘤大小、临床病理分期有关 ,随着临床病理分期 (Dukes’分期 )的上升 ,CA -Hb3水平亦明显升高。CA -Hb3水平与肿瘤部位及患者的性别、年龄等因素无关。结论 血清CA -Hb3对评估大肠癌的临床病理分期和判断临床预后有一定参考价值。
Objective To investigate the serum levels of CA -Hb3 in patients with colorectal cancer and its clinical significance. Methods Serum levels of CA-Hb3 in 72 patients with colorectal cancer were measured by ELISA. The levels of CA-Hb3 in serum of 36 healthy people were detected as control. Results The serum level of CA-Hb3 in patients with colorectal cancer was significantly higher than that in normal people. The level of CA-Hb3 was correlated with tumor size and clinicopathological stage in colorectal cancer. The level of CA -Hb3 was also significantly increased with the increase of clinical stage (Dukes’ stage) high. The level of CA -Hb3 has nothing to do with the tumor location and the patient’s gender, age and other factors. Conclusion Serum CA -Hb3 has certain reference value for assessing the clinical pathological stage and judging the clinical prognosis of colorectal cancer.