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[目的]探讨鼻咽癌根治性调强放疗(IMRT)后鼻咽溃疡发生的危险因素.[方法]回顾性分析2014年8月至2015年8月于本院行根治性IMRT后1年内发生鼻咽溃疡的80例鼻咽癌患者(溃疡组)及同期行根治性IMRT后1年内未发生鼻咽溃疡的80例鼻咽癌患者(非溃疡组)的临床资料.[结果]两组患者年龄、性别、文化程度、N分期、饮酒情况等一般资料比较,差异均无显著性(P>0.05).单因素分析显示:T分期、化疗、未鼻腔冲洗、鼻咽部剂量>72Gy、未使用抗生素、吸烟、营养不良则为影响鼻咽癌患者根治性IMRT后鼻咽溃疡发生的危险因素(P72Gy、吸烟、营养不良为影响鼻咽癌患者根治性IMRT后鼻咽溃疡发生的独立危险因素(P72Gy、吸烟、营养不良等因素均同鼻咽癌患者根治性IMRT后鼻咽溃疡的发生关系密切,需引起重视.“,”[Objective]To investigate the risk factors of nasopharyngeal ulcer after radical intensity modulated radia-tion therapy(IMRT)for nasopharyngeal carcinoma.[Methods] A retrospective analysis of 80 nasopharyngeal carcinoma patients(ulcer group)with nasopharyngeal ulcer 1 year after radical IMRT was performed in our hospital from August 2014 to August 2015.At the same time,clinical data of 80 patients with nasopharyngeal carcinoma(non ulcer group) without nasopharyngeal ulcer 1 year after radical IMRT was also analyzed(P0.05).Single factor analysis showed that T staging,chemotherapy,no nasal irrigation,nasopharynx dose>72 Gy,no use of antibiot-ics,smoking,malnutrition were the dangerous factors of the incidence of nasopharyngeal ulcer after radical IMRT in na-sopharyngeal carcinoma patients(P72 Gy,smok-ing,malnutrition and other factors are closely related to the incidence of nasopharyngeal ulcer after radical IMRT in naso-pharyngeal carcinoma patients,which should be paid attention to.