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得到性能良好的SA/PU共混微球以用于药物缓控释;方法:利用预聚-扩链-中和-分散法合成阴离子型PU水溶液;将SA水溶液与PU水溶液按质量比为1∶1,1∶2,1∶3,1∶4,1∶5混合,用滴制法制备共混微球;测定了微球的凝胶化、圆整性及溶胀性能。结果表明:用TDI与PEG-6000和PEG-4000反应才能制备出PU水溶液,而只有水溶液才能和海藻酸钠水溶液混合完全得到理想的共混溶液;SA/PU共混微球28h后凝胶化完全,SA微球48h后可凝胶化完全。PEG-6000合成的PU与海藻酸钠共混得到的微球圆整性要好于PEG-4000合成的PU与海藻酸钠共混得到的微球。且随着复合微球中PU的含量增大,微球的圆整性变好;SA/PU复合微球在蒸馏水(pH7)和盐酸(pH1)中均不溶胀,在磷酸缓冲溶液(pH6.86)中快速溶胀,在4～5h后开始崩解。结论:SA/PU复合微球在胃液中保持原状,在肠液中溶胀,可作为药物的缓释载体。
SA / PU blend microspheres with good performance were prepared for drug controlled release. Methods: The anionic PU aqueous solution was synthesized by prepolymerization-chain extension-neutralization-dispersion method. The SA aqueous solution and PU aqueous solution were mixed at a mass ratio of 1 : 1, 1: 2, 1: 3, 1: 4 and 1: 5. The microspheres were prepared by drop method. The gelation, roundness and swelling properties of the microspheres were measured. The results showed that PU solution could be prepared by reaction of TDI with PEG-6000 and PEG-4000, and only the aqueous solution could be mixed with sodium alginate solution to obtain the perfect blend solution. SA / PU blend microspheres gelled after 28h Complete, SA microspheres can be gelled completely after 48h. The microspheres obtained from PEG-6000 synthesized PU and sodium alginate had better roundness than the microspheres obtained from PEG-4000 synthesized PU and sodium alginate. The roundness of microspheres was improved with the increase of PU content in composite microspheres. SA / PU microspheres did not swell in distilled water (pH 7) and hydrochloric acid (pH 1) 86) swelled rapidly, beginning to disintegrate after 4-5 h. Conclusion: The SA / PU composite microspheres remain intact in the gastric juice and swell in the intestinal fluid, which can be used as the sustained-release carrier of the drug.