文章简介慢性痒是一种长时程的感觉异常,往往不能通过抓挠瘙痒区而改善。反复抓挠常常加重皮肤的病理改变,引起皮肤组织的酸化,后者可激活外周感觉神经元上的酸敏感离子通道(ASIC)通道。ASIC通道被激活后通透钠离子,因而调控神经元的兴奋性和感觉功能。本项研究通过急性痒觉行为测试发现,酸化本身并不致痒,但是通过依赖于ASIC3通道的新机制,显著增强了多肽类致痒剂SL-NH_2引起的痒觉。研究人员进一步发现 About the article Chronic itch is a long-term sensory abnormality that often can not be improved by scratching the itchy area. Repeated scratching often aggravates pathological changes in the skin, causing skin tissue to acidify, which activates acid-sensitive ion channel (ASIC) channels on peripheral sensory neurons. ASIC channels are activated by the permeability of sodium ions, thus regulating neuronal excitability and sensory function. In this study, acute itch behavior test found that acidification itself did not cause itch, but it significantly enhanced the itch sensation caused by the peptide priming agent SL-NH2 by a new mechanism dependent on ASIC3 channel. The researchers further found