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目的:探讨新疆地区维吾尔族与汉族结直肠癌(colorectal cancer,CRC)临床病理特征及hMLH1和hMSH2蛋白表达差异.方法:回顾性分析284例CRC患者(维吾尔族133例,汉族151例)临床病理资料,采用免疫组织化学方法对207例(维吾尔族98例,汉族109例)CRC组织中hMLH1和hMSH2蛋白的表达进行检测.结果:(1)新疆地区维吾尔族CRC患者与汉族CRC患者在发病年龄、肿瘤大小、病理分型、淋巴结转移、TNM分期间的差异均具有统计学意义(P<0.05);(2)维吾尔族CRC患者中hMLH1蛋白表达缺失率为9.2%(9/98),hMSH2蛋白表达缺失率为3.1%(3/9 8);(3)hMLH1蛋白在肿瘤最大径>5.0 cm的CRC组织中的缺失率(17.1%)明显高于肿瘤最大径≤5.0 cm的CRC组织(3.5%,P<0.05),在有淋巴结转移的CRC组织中的缺失率(15.1%)明显高于无淋巴结转移的CRC组织(2.2%,P<0.05);(4)维吾尔族CRC患者中hMSH2蛋白缺失率(3.1%)明显低于汉族CRC患者(10.1%,P<0.05).结论:新疆地区维吾尔族CRC患者较汉族患者有发病年龄较轻,肿瘤直径较大,黏液腺癌及印戒细胞癌所占比例较高,TNM分期较晚等临床病理特点;且hMSH2蛋白在维吾尔族与汉族CRC患者中的表达具有种族差异性.
Objective: To investigate the clinicopathological characteristics of colorectal cancer (CRC) and the expression of hMLH1 and hMSH2 in Uygur and Han ethnic groups in Xinjiang.Methods: The clinical data of 284 CRC patients (133 Uygur and 151 Han patients) were retrospectively analyzed. (IHC) were used to detect the expression of hMLH1 and hMSH2 in 207 CRC patients (98 Uygur and 109 Han patients) by immunohistochemistry.Results: (1) The CRC patients in Uygur Xinjiang and Han patients with CRC at the age of onset (P <0.05). (2) The loss of hMLH1 protein expression in Uighur CRC patients was 9.2% (9/98), while the expression of hMSH2 (3) The deletion rate of hMLH1 protein (17.1%) in CRC tissues with the largest diameter> 5.0 cm was significantly higher than that in CRC tissues with the largest diameter ≤5.0 cm 3.5%, P <0.05). The deletion rate (15.1%) in CRC tissues with lymph node metastasis was significantly higher than that in CRC tissues without lymph node metastasis (2.2%, P <0.05) The protein deletion rate (3.1%) was significantly lower than that of CRC patients (10.1%, P <0.05) .Conclusion: Minority CRC patients than Han patients with younger age, tumor diameter larger, mucinous adenocarcinoma and signet-ring cell carcinoma of the higher proportion of TNM staging later clinical and pathological features; and hMSH2 protein in the Uygur and Han CRC The patient’s expression is racially differentiated.