肿瘤血管生成对于肿瘤的发生、发展是至关重要的,因此肿瘤血管生成模式的研究意义重大。Maniotis等提出了一种全新的肿瘤血管生成模式——拟态血管生成,他们利用CD34-PAS双重染色等方法来区分拟态血管和传统的肿瘤血管。拟态血管发生的分子调控涉及许多与内皮细胞和造血干细胞表型相关基因的异常表达。目前研究认为恶性程度高的肿瘤中才有拟态血管,所以对其研究可以更好地指导临床治疗和判断预后。肿瘤学界对拟态血管生成现象还存在许多争论,焦点集中在拟态血管是否是一种假象,以及其鉴定的可靠方法。拟态血管生成现象对目前单纯针对传统的肿瘤血管的治疗策略提出了挑战,它可能成为未来治疗高度恶性肿瘤的一个新的靶点。 Tumor angiogenesis is crucial for tumorigenesis and development. Therefore, the study of tumor angiogenesis is of great significance. Maniotis et al. Proposed a new model of tumor angiogenesis, mimic angiogenesis. They used the method of CD34-PAS double staining to distinguish between mimic vessels and traditional tumor vessels. Molecular regulation of mimicry angiogenesis involves many aberrant expression of genes associated with endothelial cells and hematopoietic stem cell phenotypes. The current study suggests that the tumor with high degree of malignancy only mimic vascular, so its research can better guide the clinical treatment and prognosis. There is still much debate in the oncology community about the phenomenon of mimicry angiogenesis, with the focus on whether mimicry blood vessels are an illusion or not and the reliable methods for their identification. The phenomenon of mimic angiogenesis poses a challenge to the treatment strategy of traditional tumor vessels at present, which may become a new target for the treatment of highly malignant tumors in the future.