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[目的]分析131I治疗甲状腺功能亢进症(甲亢)患者的临床和随访资料,总结临床疗效。[方法]患者在治疗前后均完成甲状腺功能、肝肾功能、血尿常规、心电图、B超检查及甲状腺摄131I率测定、甲状腺显像;禁碘,使用抗甲状腺药物治疗者须停药1个月。给131I剂量按公式:甲状腺重量×每克甲状腺组织给131I量/24h摄131I率计算。甲状腺重量采用手法测量估计结合甲状腺SPECT扫描显像及B超检查确定。每克甲状腺组织给药量为2.6～3.7MBq,并根据患者病程、甲状腺大小、质地和既往治疗情况加以适当调整。均一次口服,治疗后3、6、12个月定期复查,以后每年复查1次,随访时间5年以上。[结果]200例患者中,5年总有效率98.5%,总治愈率81.0%,甲减18.0%。[结论]131I是治疗甲亢有效、经济、安全的方法,选择适当的剂量,坚持个体化方案,加强随访指导,可将131I治疗引发的甲减发生率控制在较理想水平。
[Objective] To analyze the clinical and follow-up data of 131I in the treatment of hyperthyroidism (Hyperthyroidism) and summarize the clinical curative effect. [Methods] Thyroid function, liver and kidney function, hematuria, electrocardiogram, B-ultrasound and thyroid uptake were determined before and after treatment in 131I patients. Thyroid imaging was used. Forbidden iodine and antithyroid drugs treatment should be stopped for 1 month . To 131I dose according to the formula: thyroid weight × per thyroid tissue to give 131I amount / 24h photo 131I rate calculation. Thyroid weight was measured by manual method combined with thyroid SPECT scan imaging and B-ultrasound to determine. Per gram of thyroid tissue dosage of 2.6 ~ 3.7MBq, and according to the patient’s duration, thyroid size, texture and previous treatment to be appropriately adjusted. All were orally, 3,6,12 months after treatment regular review, after an annual review of 1, follow-up time of 5 years. [Result] Among the 200 patients, the total effective rate was 98.5% in 5 years, the total cure rate was 81.0% and the hypothyroidism rate was 18.0%. [Conclusion] 131I is an effective, economical and safe method for the treatment of hyperthyroidism. With 131I treatment, the incidence of hypothyroidism can be controlled at an ideal level by selecting the appropriate dose, adhering to the individualized scheme and strengthening follow-up guidance.